"The ability of RVX-208 to enhance cholesterol efflux is the first and most important step in reverse cholesterol transport, the process by which cholesterol is removed from the wall of the arteries. Our data show that RVX-208 stimulates the production Apolipoprotein A-I, the major protein component of HDL to trigger the formation of early HDL particles, (so called pre-beta HDL particles) which play the key role in removing cholesterol from cells; this, in turn raise the total mass of HDL-C. This change in HDL profile towards the early, or 'nascent' HDL particles is believed to be an important factor in promoting RCT," said Dr. Jacques Genest, MD, Professor, Faculty of Medicine at McGill University and Director of the Division of Cardiology at the Royal Victoria Hospital of the RI of the MUHC.

The first author in the JACC article is Ms. Dana Bailey who leads a team comprised of many scientific members of Resverlogix. This article is also available online through the electronic edition of the Journal of American College of Cardiology (www.onlinejacc). JACC is considered by many as the premiere journal in the field of clinical cardiology.

Resverlogix is also pleased to announce the publication of an additional peer reviewed journal article entitled "Stilbene Analogs as Inducers of ApoA-l Transcription." It appeared in the European Journal of Medicinal Chemistry 2010, 45, 2018-2023, a leading publication devoted to topics in chemistry. The topic of this manuscript details the ability of novel compounds to stimulate ApoA-I gene transcription.

SOURCE Resverlogix Corp.