Roche NimbleGen was the first company to offer a commercial solution for sequence capture and exome capture. Based on the success of the NimbleGen Sequence Capture 2.1M Exome Arrays which have enabled researchers worldwide to sequence thousands of exomes since late 2008, Roche NimbleGen launched SeqCap EZ Exome technology at the end of 2009. This new technology employs an in-solution method that simplifies the workflow, provides high-quality targeted capture/enrichment, and is scalable to easily facilitate research studies of any size.
In a recent study published in Genome Biology, scientists from the HGSC at Baylor and at Roche NimbleGen used SeqCap EZ Exome to demonstrate that as little as 3 Gb of raw sequence data is needed to discover >95% of expected heterozygous single base variants. In this study, SeqCap EZ Exome technology was coupled with multiple high throughput sequencing platforms for efficient resequencing of protein coding regions within the human genome.
"Roche NimbleGen is committed to providing the best exome capture technology for researchers worldwide," stated Dr. Andreas G?śrtz, VP of Marketing at Roche NimbleGen. "We believe studies like these carried out by leading research centers like the Baylor Human Genome Sequencing Center will provide insights on the missing heritability of many genetic diseases, hopefully leading to future breakthroughs in diagnostic and therapeutic tools."
SOURCE Roche NimbleGen