"Our research benefits from a multidisciplinary approach and a willingness to share diverse expertise in working toward a common goal," he said. "Models generated for one project are pivotal for the other projects, just as the physiological or molecular expertise of one project leader will be critical to the success of future projects."

The five laboratories involved in the project will work individually on two common areas: identifying the critical sites of action for lipid-related inflammation in the periphery of the body as well as the brain, and identifying the biochemical signals that take place in the body after exposure to high-fat, lipid-rich foods. Lipids encompass a broad group of naturally occurring molecules, including fats, fatty acids and cholesterol.

Dr. Scherer said the team hypothesizes that the vagus nerve, which stretches from the brain stem into the abdomen, acts as a key link between the liver and the molecules involved in metabolism, such as hormones and lipids. Activation of this nerve affects parts of the brain associated with feeding and control of basic functions like heart rate and blood pressure.

The researchers also speculate, based on prior findings, that sensory neurons found within this nerve might be equipped to serve as a link between adipose tissue and the liver.

The award also will enable the researchers to characterize which genes are active in these vagus sensory neurons, Dr. Scherer said.

Source UT Southwestern